α-肾上腺素能阻滞剂对新生羔羊肺血管对多巴胺反应的影响。

The effect of alpha-adrenergic blockade on the pulmonary vascular response to dopamine in neonatal lambs.

作者信息

Williams B J, Drummond W H

出版信息

Pediatr Res. 1983 Jun;17(6):464-7. doi: 10.1203/00006450-198306000-00007.

DOI:10.1203/00006450-198306000-00007

Abstract

The effect of alpha-adrenergic blockade by phentolamine on the pulmonary vascular response to dopamine was studied in chronically prepared newborn lambs. Dopamine was administered at doses of 2.7 micrograms . kg-1 . min-1, 27 micrograms . kg-1 . min-1 and 270 micrograms . kg-1 . min-1 with and without alpha-adrenergic blockade. Dopamine infusion at 270 micrograms . kg-1 . min-1 caused a rise in the mean pulmonary artery pressure from 22 +/- 3.2 mmHg (mean +/- S.E.) at baseline to 36 +/- 4.1 mmHg (P less than 0.001). This rise was unaffected by alpha-adrenergic blockade. Dopamine infusion alone did not change pulmonary blood flow, but, in the presence of alpha-adrenergic blockade, pulmonary blood flow rose from 190 +/- 12 ml . min-1 . kg-1 at baseline to 280 +/- 13 ml . min-1 . kg-1 at the maximum dopamine infusion rate (P less than 0.001). Pulmonary vascular resistance was the same before and after alpha-adrenergic blockade and did not change from the baseline value during dopamine infusion.

摘要

在长期制备的新生羔羊中研究了酚妥拉明对α-肾上腺素能的阻滞作用对多巴胺引起的肺血管反应的影响。在有和没有α-肾上腺素能阻滞的情况下，分别以2.7微克·千克⁻¹·分钟⁻¹、27微克·千克⁻¹·分钟⁻¹和270微克·千克⁻¹·分钟⁻¹的剂量给予多巴胺。以270微克·千克⁻¹·分钟⁻¹的速度输注多巴胺导致平均肺动脉压从基线时的22±3.2 mmHg（平均值±标准误）升至36±4.1 mmHg（P<0.001）。这种升高不受α-肾上腺素能阻滞的影响。单独输注多巴胺不会改变肺血流量，但在存在α-肾上腺素能阻滞的情况下，肺血流量从基线时的190±12毫升·分钟⁻¹·千克⁻¹升至多巴胺最大输注速率时的280±13毫升·分钟⁻¹·千克⁻¹（P<0.001）。α-肾上腺素能阻滞前后肺血管阻力相同，并且在多巴胺输注期间与基线值相比没有变化。