Manigand G, Faux N, Dumas D, Taillandier J, Fixy P, Richerd F
Sem Hop. 1983 Jun 16;59(24):1840-1.
Two patients under cytotoxic therapy developed pigmentation of their fingernails. The first, under doxorubicin and cyclophosphamide for lymphoma, had horizontal streaks, while the second, under cyclophosphamide for periarteritis nodosa, exhibited diffuse pigmentation. Nail pigmentation, which occurs after an interval of some weeks or months, varies from diffuse to horizontal or longitudinal streaks. Reversal of nail pigmentation some months after withdrawal of the drug is usual. Skin or mucous membrane pigmentation may coexist. The mechanism of pigmentation remains obscure. These changes are observed more frequently in black than in white patients. In some instances, they have been recorded in several members of the same family.
两名接受细胞毒性治疗的患者出现了指甲色素沉着。第一名患者因淋巴瘤接受阿霉素和环磷酰胺治疗，指甲出现水平条纹；第二名患者因结节性多动脉炎接受环磷酰胺治疗，表现为弥漫性色素沉着。指甲色素沉着在数周或数月后出现，从弥漫性到水平或纵向条纹不等。停药数月后指甲色素沉着通常会消退。皮肤或黏膜色素沉着可能同时存在。色素沉着的机制尚不清楚。这些变化在黑人患者中比在白人患者中更常见。在某些情况下，同一家庭的几名成员都有记录。
