Department of Dermatology and Department of Oncology, Teaching Hospital, Anuradhapura, Sri Lanka.
Clin Exp Dermatol. 2009 Dec;34(8):e920-6. doi: 10.1111/j.1365-2230.2009.03713.x.
The study was carried out on 17 patients (16 female, 1 male) who presented with nail pigmentation after chemotherapy. Ten patients who were given cyclophosphamide had diffuse black pigmentation, slate-grey to black longitudinal streaks, or diffuse dark-grey pigmentation located proximally with overlying black transverse bands. The pigmentation appearing after hydroxyurea was located more distally, was brownish-black in colour and diffuse, or appeared in single or double transverse bands. Diffuse pigmentation of the skin, patchy macular pigmentation of the gum margins, and the tip and lateral margins of the tongue were also seen. In patients on carboplatin treatment, brown pigmentation in bands 2-4 mm wide was seen, located distally on the fingernails. Black longitudinal bands on a background of diffuse brown pigmentation were noted after docetaxel treatment. Chemotherapy-induced nail pigmentation in patients skin type V is not an uncommon event, which is probably underestimated and under-reported.
本研究纳入了 17 名化疗后出现甲色素沉着的患者（16 名女性，1 名男性）。10 名接受环磷酰胺治疗的患者出现弥漫性黑色色素沉着、石板灰色至黑色纵向条纹，或弥漫性深灰色色素沉着位于近端，伴有上方黑色横行条纹。羟基脲治疗后出现的色素沉着位于更远端，呈棕黑色弥漫性，或呈单个或双横行条纹。还观察到皮肤弥漫性色素沉着、牙龈边缘斑片状黄斑色素沉着以及舌尖和侧缘。卡铂治疗的患者指甲上可见 2-4mm 宽的棕色色素带，位于远端。多西他赛治疗后可见弥漫性棕色色素沉着背景上的黑色纵向条纹。在 V 型皮肤类型的患者中，化疗引起的指甲色素沉着并非罕见事件，但可能被低估和漏报。
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