Cenacchi G, Ballardini G, Badiali De Giorgi L, Busachi C A, Del Rosso M, Bianchi F B, Biagini G, Laschi R
Virchows Arch B Cell Pathol Incl Mol Pathol. 1983;43(1):75-84. doi: 10.1007/BF02932946.
The cellular and non-cellular components of fibrous septa formed at early and late stages in a sequential model of experimental hepatic fibrosis have been investigated using ultrastructural and immunocytochemical techniques. In the early septa, cells with intermediate features between lobular Ito cells and active fibroblasts were formed. These cells frequently displayed subplasmalemmal microfilaments (myofibroblast-like cells). Macrophages were also present. Scanty typical fibroblasts were present in the late septa. This cellular recruitment might be related to an extracellular glycoprotein-fibronectin-which is at present under investigation as a chemotactic factor for fibroblasts. Strong positivity for fibronectin in early septa and its sharp decrease in late septa seems to support this view. Fibroblasts and/or macrophages are the likely source of fibronectin synthesis.
运用超微结构和免疫细胞化学技术，对实验性肝纤维化连续模型早期和晚期形成的纤维间隔的细胞和非细胞成分进行了研究。在早期间隔中，形成了具有小叶内 Ito 细胞和活跃成纤维细胞中间特征的细胞。这些细胞经常显示出亚浆膜微丝（肌成纤维细胞样细胞）。巨噬细胞也存在。晚期间隔中存在少量典型的成纤维细胞。这种细胞募集可能与一种细胞外糖蛋白——纤连蛋白有关，目前正在研究其作为成纤维细胞的趋化因子。早期间隔中纤连蛋白的强阳性及其在晚期间隔中的急剧下降似乎支持了这一观点。成纤维细胞和/或巨噬细胞可能是纤连蛋白合成的来源。
