Daudon M, Protat M F, Reveillaud R J
Ann Biol Clin (Paris). 1983;41(2):105-11.
The role of glafenine in certain cases of acute renal failure was described several years ago, but very little work has been done on the intratubular precipitates generally responsible for these manifestations. We have been able to study 6 cases of acute poisoning and 5 cases of glafenine renal stones which have shown that several mechanisms are likely to be involved. In 4 cases, the acute poisoning resulted in reversible oliguria which resolved after several days. In 3 of the 5 cases of renal stones, variable amounts of glafenine were found in the zone of nucleation. Infrared spectrophotometric and chromatographic examination of the first urine after the return of diuresis in the oliguric subjects and in the patients with renal stones, revealed that several metabolites of glafenine could be implicated in the development of these renal precipitates. In the different cases, free metabolites and conjugated derivatives were found to be responsible. The authors discuss the relationship between the products detected and the clinical manifestations observed.
几年前就已描述了格拉非宁在某些急性肾衰竭病例中的作用，但对于通常导致这些表现的肾小管内沉淀物的研究却很少。我们得以研究6例急性中毒病例和5例格拉非宁肾结石病例，结果表明可能涉及多种机制。在4例急性中毒病例中，出现了可逆性少尿，数日后尿量恢复正常。在5例肾结石病例中的3例中，在成核区域发现了不同量的格拉非宁。对少尿患者和肾结石患者利尿恢复后首次尿液进行的红外分光光度法和色谱检查显示，格拉非宁的几种代谢产物可能与这些肾脏沉淀物的形成有关。在不同病例中，发现游离代谢产物和结合衍生物是罪魁祸首。作者讨论了检测到的产物与观察到的临床表现之间的关系。
