Zavanella T, Presta M, Ragnotti G
Cancer Lett. 1983 Jul;19(3):293-9. doi: 10.1016/0304-3835(83)90097-6.
The morphology of the thyroid gland from Wistar rats treated for 6 months with the beta-blocker DL-1-(2-nitro-5-methyl-phenoxy)-3-tert-butyl-amino-propan-2-ol (ZAMI 1305), a potent sex-dependent hepatocarcinogen, was studied. A significant high incidence of cases with thyroid hyperplasia is found among female rats, the only sex susceptible to the carcinogenic effect of ZAMI 1305. Thyroid hyperplasia is instead much less evident in male rats. In female rats the increase in the relative thyroid weight is directly related to the gravity of the predominant liver lesion (clear cell foci, neoplastic nodules, hepatocellular carcinomas). The results suggest an influence of the preneoplastic and neoplastic liver on thyroid gland.
研究了用β受体阻滞剂DL-1-(2-硝基-5-甲基-苯氧基)-3-叔丁基-氨基-丙-2-醇（ZAMI 1305，一种强效的性别依赖性肝致癌物）处理6个月的Wistar大鼠甲状腺的形态。在雌性大鼠中发现甲状腺增生病例的发生率显著较高，雌性是唯一对ZAMI 1305致癌作用敏感的性别。相反，甲状腺增生在雄性大鼠中则不那么明显。在雌性大鼠中，相对甲状腺重量的增加与主要肝脏病变（透明细胞灶、肿瘤结节、肝细胞癌）的严重程度直接相关。结果表明，癌前和肿瘤性肝脏对甲状腺有影响。
