Mattila M A, Suurinkeroinen S, Säilä K, Himberg J J
Int J Clin Pharmacol Ther Toxicol. 1983 Jun;21(6):284-6.
Flunitrazepam premedication administered orally or intramuscularly was compared in 41 surgical patients. The effect of the premedication was assessed both subjectively and objectively. The plasma concentrations were determined just before induction. The mean (+/-SD) plasma concentration in the oral premedication group was 8.2 +/- 2.2 ng/ml and 7.9 +/- 4.6 ng/ml in the intramuscular premedication group. There was a highly significant correlation (p less than 0.001) between the sedative effect and plasma concentration of flunitrazepam in all patients. Oral flunitrazepam was equal to i. m. flunitrazepam as an anxiolytic and sedative with a rapid onset of action. However, the oral route of administration of flunitrazepam is preferable because it is painless and easy to administer.
对41例外科手术患者比较了口服和肌肉注射氟硝西泮进行术前用药的效果。通过主观和客观评估术前用药的效果。在诱导前即刻测定血浆浓度。口服术前用药组的平均（±标准差）血浆浓度为8.2±2.2 ng/ml，肌肉注射术前用药组为7.9±4.6 ng/ml。所有患者中，氟硝西泮的镇静效果与血浆浓度之间存在高度显著相关性（p<0.001）。口服氟硝西泮作为一种抗焦虑和镇静药物，起效迅速，与肌肉注射氟硝西泮效果相当。然而，氟硝西泮的口服给药途径更可取，因为它无痛且易于给药。
