Balasch J, Vanrell J A, Durán M, González-Merlo J
Int J Fertil. 1983;28(2):104-6.
Fifty infertile patients treated with clomiphene and hCG for induction of ovulation were studied with plasma progesterone measurement and endometrial histology. Five patients (10%) presented defective endometria and low plasma progesterone in spite of biphasic BBT charts with normal luteal phase length. Forty-five patients (90%) had significantly higher plasma progesterone concentrations than those found in a control group of fertile women, but a defective endometrial secretory pattern occurred in 19 of these 45 patients (42.3%). These data suggest the need for monitoring the response to clomiphene by endometrial histology in addition to BBT and plasma progesterone, or for supplemental therapy to overcome the endometrial luteal phase deficiency in clomiphene-treated cycles.
对50例接受克罗米芬和人绒毛膜促性腺激素诱导排卵治疗的不孕患者进行了血浆孕酮测定和子宫内膜组织学研究。尽管基础体温双相且黄体期长度正常，但仍有5例患者（10%）出现子宫内膜缺陷和血浆孕酮水平低的情况。45例患者（90%）的血浆孕酮浓度明显高于可育女性对照组，但这45例患者中有19例（42.3%）出现子宫内膜分泌模式缺陷。这些数据表明，除基础体温和血浆孕酮外，还需要通过子宫内膜组织学监测对克罗米芬的反应，或采用补充疗法来克服克罗米芬治疗周期中的子宫内膜黄体期缺陷。
