人类阴茎海绵体肌中的胆碱能受体。

Cholinoreceptors in the corpus cavernosum muscle of the human penis.

作者信息

Adaikan P G, Karim S M, Kottegoda S R, Ratnam S S

出版信息

J Auton Pharmacol. 1983 Jun;3(2):107-11. doi: 10.1111/j.1474-8673.1983.tb00526.x.

DOI:10.1111/j.1474-8673.1983.tb00526.x

Abstract

Acetylcholine produced contraction, relaxation or a biphasic effect on corpus cavernosum muscle strips of human penis. These effects were antagonized by atropine but were modified by hexamethonium or tetrodotoxin suggesting the presence of excitatory and inhibitory muscarinic receptors in the human penis. Nicotine and DMPP also produced contraction or relaxation of the corpus cavernosum muscle strips. These effects were presumably indirect as they were abolished by hexamethonium and tetrodotoxin. Contractions produced by nicotine or DMPP were abolished by atropine whereas the relaxations produced by these agents were only partially blocked by atropine. Hence, the receptors mediating these relaxations are unlikely to be entirely muscarinic.

摘要

乙酰胆碱对人阴茎海绵体肌条产生收缩、舒张或双相效应。这些效应被阿托品拮抗，但被六甲铵或河豚毒素改变，提示人阴茎中存在兴奋性和抑制性毒蕈碱受体。尼古丁和二甲基苯基哌嗪也可使海绵体肌条收缩或舒张。这些效应可能是间接的，因为它们被六甲铵和河豚毒素消除。尼古丁或二甲基苯基哌嗪引起的收缩被阿托品消除，而这些药物引起的舒张仅被阿托品部分阻断。因此，介导这些舒张的受体不太可能完全是毒蕈碱受体。