维拉帕米对离体灌注兔耳动脉的多巴胺拮抗作用。
Dopamine antagonist effect of verapamil on isolated perfused rabbit ear artery.
作者信息
Johnson C E, Steinsland O S, Scriabine A
出版信息
J Pharmacol Exp Ther. 1983 Sep;226(3):802-5.
Rabbit ear arteries were isolated and perfused with Krebs-bicarbonate solution. Brief periods of supramaximal nerve stimulation caused reproducible constriction of the arteries, which was inhibited by dopamine at concentrations ranging from 3.3 X 10(-9) to 3.3 X 10(-7) M. The inhibitory effect of dopamine was antagonized by sulpiride and by verapamil. The dose-response curve to dopamine was shifted to the right by both sulpiride and verapamil, indicative of competitive inhibition. The dopamine antagonist activity of verapamil does not appear to be a consequence of its Ca++ channel inhibitory activity because other calcium antagonists (e.g., nitrendipine and diltiazem) had no similar action.
分离兔耳动脉并用碳酸氢盐缓冲液进行灌注。短时间的超强神经刺激可引起动脉重复性收缩，多巴胺在浓度范围为3.3×10⁻⁹至3.3×10⁻⁷M时可抑制这种收缩。舒必利和维拉帕米可拮抗多巴胺的抑制作用。舒必利和维拉帕米均使多巴胺的剂量-反应曲线右移，提示为竞争性抑制。维拉帕米的多巴胺拮抗活性似乎并非其钙通道抑制活性的结果，因为其他钙拮抗剂（如尼群地平和地尔硫䓬）无类似作用。
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