Ishii A, Cabrera B D, Suguri S, Kobayashi M, Go T G, Valeza F
J Trop Med Hyg. 1983 Apr;86(2):59-64.
An epidemiological survey was conducted on Bancroftian filariasis in Sorsogon province, the Philippines, with special regard to low density microfilaremia (LDF). Filtration technique using nuclepore membrane examining 1 ml blood revealed 31% positive rate for microfilaria out of 262 volunteers. Out of 82 positives 21 (25.6%) had LDF (less than 10 in 1 ml blood). No conspicuous grouping of LDF was noted in younger age groups or sexes. In three out of 12 clinical filariasis, microfilaria was detected but none of them were LDF. Among 22 cases treated with diethylcarbamazine, nine subsequently had LDF suggesting necessity of improvement of drug administration regimen to avoid incomplete treatment. A series of feeding experiments using two mosquito species, Aedes poicilius and Culex quinquefasciatus, on volunteers showed that both species could act as vectors in the region. No larva was detected in either species fed on LDF carriers. It was concluded that there is little possibility that LDF plays an important role in the transmission of Bancroftian filariasis in the region.
在菲律宾索索贡省针对班氏丝虫病开展了一项流行病学调查，特别关注低密度微丝蚴血症（LDF）。使用核孔膜的过滤技术检查1毫升血液，在262名志愿者中发现微丝蚴阳性率为31%。在82名阳性者中，21人（25.6%）患有LDF（每毫升血液中少于10条）。在较年轻年龄组或不同性别中未发现LDF有明显的聚集情况。在12例临床丝虫病病例中有3例检测到微丝蚴，但均非LDF。在接受乙胺嗪治疗的22例病例中，9例随后出现LDF，这表明有必要改进给药方案以避免治疗不彻底。对志愿者进行的一系列使用两种蚊虫（白纹伊蚊和致倦库蚊）的叮咬实验表明，这两种蚊虫均可作为该地区的传播媒介。以LDF携带者为食的两种蚊虫均未检测到幼虫。得出的结论是，在该地区LDF在班氏丝虫病传播中发挥重要作用的可能性很小。
