Satoh H, Satoh Y, Mori J
Jpn J Pharmacol. 1983 Apr;33(2):363-72. doi: 10.1254/jjp.33.363.
The effect of zotepine (2-chloro-11-(2-dimethyl-aminoethoxy) dibenzo [b, f] thiepin), a new neuroleptic, and other neuroleptics, minor tranquilizers, antidepressants, anticholinergic drugs, antihistamine drugs, antiparkinsonian drugs, alpha-, beta-adrenergic blocking agents, hypnotics and central muscle relaxants on apomorphine (APM)- and methamphetamine (MAP)-induced rotational behaviour was investigated in rats with unilateral lesions of the substantia nigra. Only the neuroleptics dose-dependently depressed both rotational behaviours. The minor tranquilizers also depressed both behaviours, but their effect was non-specific. The neuroleptics could be divided into two groups according to their relative effect on the APM- and MAP-induced rotational behaviour. The high-ratio group (fluphenazine, haloperidol, perphenazine, pimozide and zotepine) depressed the MAP-induced rotational behaviour more strongly than the APM-induced one, whereas the depressive effect of the low-ratio group (chlorpromazine, levomepromazine, thioridazine and clozapine) was the reverse. Zotepine, while belonging to the high-ratio group, was markedly lower in ratio than the other neuroleptics in this group. The correlation between the different effect of the two groups of neuroleptics and their clinical effect is discussed.
对患有单侧黑质损伤的大鼠，研究了新型抗精神病药佐替平（2-氯-11-（2-二甲基氨基乙氧基）二苯并[b,f]硫氮杂䓬）以及其他抗精神病药、弱安定药、抗抑郁药、抗胆碱能药、抗组胺药、抗帕金森病药、α-、β-肾上腺素能阻滞剂、催眠药和中枢性肌肉松弛剂对阿扑吗啡（APM）和甲基苯丙胺（MAP）诱导的旋转行为的影响。只有抗精神病药能剂量依赖性地抑制两种旋转行为。弱安定药也能抑制这两种行为，但其作用是非特异性的。根据抗精神病药对APM和MAP诱导的旋转行为的相对作用，可将其分为两组。高比值组（氟奋乃静、氟哌啶醇、奋乃静、匹莫齐特和佐替平）对MAP诱导的旋转行为的抑制作用比对APM诱导的更强，而低比值组（氯丙嗪、左美丙嗪、硫利达嗪和氯氮平）的抑制作用则相反。佐替平虽属于高比值组，但其比值明显低于该组的其他抗精神病药。文中讨论了两组抗精神病药不同作用与其临床疗效之间的相关性。
