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阿尔茨海默病与老年痴呆症的神经化学

The neurochemistry of Alzheimer's disease and senile dementia.

作者信息

Davies P

出版信息

Med Res Rev. 1983 Jul-Sep;3(3):221-36. doi: 10.1002/med.2610030302.

Abstract

At this time we seem to be on the verge of opening two new fields of research on Alzheimer's disease. To treat the symptoms of this condition, an understanding of the factors regulating acetylcholine synthesis will be very important. Because of the vast amount of work on this neurotransmitter over the last 30 years, rapid progress in this area should be made. However, to truely conquer Alzheimer's disease, we need to learn what it is that attacks and apparently destroys the cholinergic neurons. While this second point may take a little more time to unravel, the work will be both exciting and very worth while.

摘要

此时,我们似乎即将开启阿尔茨海默病研究的两个新领域。为了治疗这种疾病的症状,了解调节乙酰胆碱合成的因素将非常重要。由于在过去30年里对这种神经递质进行了大量研究,该领域有望取得快速进展。然而,要真正攻克阿尔茨海默病,我们需要弄清楚是什么攻击并明显破坏了胆碱能神经元。虽然第二点可能需要更多时间来解开谜团,但这项工作将既令人兴奋又非常值得。

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