α-肾上腺素能受体拮抗剂对大鼠大脑皮层切片中5-羟色胺和去甲肾上腺素释放的影响。去甲肾上腺素摄取抑制的影响及pA2值的测定。 - Suppr

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Effects of alpha-adrenoceptor antagonists on the release of serotonin and noradrenaline from rat brain cortex slices. Influence of noradrenaline uptake inhibition and determination of pA2 values.

作者信息

Schlicker E, Göthert M, Köstermann F, Clausing R

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):106-13. doi: 10.1007/BF00634257.

DOI:10.1007/BF00634257

PMID:6136917

Abstract

摘要

相似文献

Effects of alpha-adrenoceptor antagonists on the release of serotonin and noradrenaline from rat brain cortex slices. Influence of noradrenaline uptake inhibition and determination of pA2 values.α-肾上腺素能受体拮抗剂对大鼠大脑皮层切片中5-羟色胺和去甲肾上腺素释放的影响。去甲肾上腺素摄取抑制的影响及pA2值的测定。

Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):106-13. doi: 10.1007/BF00634257.

Relationship between transmitter uptake inhibition and effects of alpha-adrenoceptor agonists on serotonin and noradrenaline release in the rat brain cortex.递质摄取抑制与α-肾上腺素能受体激动剂对大鼠大脑皮层中5-羟色胺和去甲肾上腺素释放的影响之间的关系。

Naunyn Schmiedebergs Arch Pharmacol. 1983 Mar;322(2):121-8. doi: 10.1007/BF00512384.

The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype.大鼠脑突触体中[3H]去甲肾上腺素和[3H]5-羟色胺释放的调节并非由α2B-肾上腺素能受体亚型介导。

Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):382-6. doi: 10.1007/BF00169453.

Modulation of gamma-[3H]aminobutyric acid release from rat cortical slices by alpha 2-adrenoceptors.

Neurosci Lett. 1987 Oct 5;80(3):309-14. doi: 10.1016/0304-3940(87)90473-3.

Regulation of noradrenaline release from rat occipital cortex tissue chops by alpha 2-adrenergic agonists.α2-肾上腺素能激动剂对大鼠枕叶皮质组织块去甲肾上腺素释放的调节

J Neurochem. 1991 Apr;56(4):1387-93. doi: 10.1111/j.1471-4159.1991.tb11436.x.

Modulation of 5-hydroxytryptamine release by presynaptic inhibitory alpha 2-adrenoceptors in the human cerebral cortex.人类大脑皮层中突触前抑制性α2肾上腺素能受体对5-羟色胺释放的调节作用。

Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):508-12. doi: 10.1007/BF00169037.

Different alpha-adrenoceptors modulate the release of 5-hydroxytryptamine and noradrenaline in rat cortex.不同的α-肾上腺素能受体调节大鼠皮层中5-羟色胺和去甲肾上腺素的释放。

Br J Pharmacol. 1983 May;79(1):279-83. doi: 10.1111/j.1476-5381.1983.tb10522.x.

Evidence for a functional alpha 1A- (alpha 1C-) adrenoceptor mediating contraction of the rat epididymal vas deferens and an alpha 1B-adrenoceptor mediating contraction of the rat spleen.有证据表明，功能性α1A-（α1C-）肾上腺素能受体介导大鼠附睾输精管收缩，而α1B-肾上腺素能受体介导大鼠脾脏收缩。

Br J Pharmacol. 1995 Jun;115(3):467-75. doi: 10.1111/j.1476-5381.1995.tb16356.x.

Differential alpha-mediated inhibition of dopamine and noradrenaline release in the parietal and occipital cortex following noradrenaline transporter blockade.去甲肾上腺素转运体阻断后，α介导的顶叶和枕叶皮质中多巴胺和去甲肾上腺素释放的差异性抑制。

J Neurochem. 2006 Jul;98(1):113-21. doi: 10.1111/j.1471-4159.2006.03851.x.

All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons.所有三种α2 -肾上腺素能受体类型在节后交感神经元中均作为自身受体发挥作用。

Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):504-12. doi: 10.1007/s00210-003-0829-x. Epub 2003 Nov 11.

引用本文的文献

Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).血清素与超越——纪念曼弗雷德·格特（1939-2019）。

Naunyn Schmiedebergs Arch Pharmacol. 2021 Sep;394(9):1829-1867. doi: 10.1007/s00210-021-02083-5. Epub 2021 May 15.

In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of alpha 2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus.体内电生理证据表明，内源性去甲肾上腺素对大鼠海马体中5-羟色胺终端的α2-肾上腺素能受体有持续性激活作用。

Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):266-72. doi: 10.1007/BF00167444.

GABAB receptor-mediated inhibition of serotonin release in the rat brain.大鼠脑中GABAB受体介导的5-羟色胺释放抑制作用

Naunyn Schmiedebergs Arch Pharmacol. 1984 Jun;326(2):99-105. doi: 10.1007/BF00517304.

Proceedings of the British Pharmacological Society. 9th-11th September 1985. Abstracts.英国药理学会会议记录。1985年9月9日至11日。摘要

Br J Pharmacol. 1985 Dec;86 Suppl(Suppl):527P-820P.

Serotonin (5-HT) enhances hippocampal noradrenaline (NA) release: evidence for facilitatory 5-HT receptors within the CNS.血清素（5-羟色胺，5-HT）增强海马体去甲肾上腺素（NA）释放：中枢神经系统内存在促进性5-HT受体的证据。

Naunyn Schmiedebergs Arch Pharmacol. 1986 Jul;333(3):191-7. doi: 10.1007/BF00512929.

Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT-receptor agonists.内源性去甲肾上腺素作为海马5-羟色胺（5-HT）释放的调节剂。育亨宾、萝芙辛和柯楠因作为α-肾上腺素能受体拮抗剂和5-HT受体激动剂的双重作用。

Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):216-21. doi: 10.1007/BF00501871.

Effect of chlorpromazine on sympathetic neuroeffector transmission in the rabbit isolated pulmonary artery and aorta.氯丙嗪对兔离体肺动脉和主动脉交感神经效应器传递的影响。

Br J Pharmacol. 1988 Jan;93(1):23-34. doi: 10.1111/j.1476-5381.1988.tb11401.x.

Neuropeptide Y increases the inhibitory effects of clonidine on potassium evoked 3H-noradrenaline but not 3H-5-hydroxytryptamine release from synaptosomes of the hypothalamus and the frontoparietal cortex of the male Sprague-Dawley rat.

J Neural Transm Gen Sect. 1989;78(1):61-72. doi: 10.1007/BF01247114.

Phentolamine blocks presynaptic serotonin autoreceptors in rabbit and rat brain cortex.酚妥拉明可阻断家兔和大鼠大脑皮层中的突触前5-羟色胺自身受体。

Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):52-61. doi: 10.1007/BF00169207.

Different effects of serotonin (5-HT) uptake blockers in caudate nucleus and hippocampus of the rabbit: role of monoamine oxidase in dopaminergic terminals.血清素（5-羟色胺，5-HT）摄取阻滞剂对兔尾状核和海马的不同作用：单胺氧化酶在多巴胺能终末的作用

Psychopharmacology (Berl). 1992;106(1):118-26. doi: 10.1007/BF02253598.

本文引用的文献

Effects of 4-chloro-2-(2-imidazolin-2-ylamino)-isoindoline Hydrochloride (BE 6143) at pre- and postsynaptic alpha-adrenoceptors in rabbit aorta and pulmonary artery.4-氯-2-(2-咪唑啉-2-基氨基)异吲哚啉盐酸盐（BE 6143）对兔主动脉和肺动脉突触前及突触后α-肾上腺素能受体的作用。

Arzneimittelforschung. 1982;32(12):1534-40.

Presynaptic regulation of the release of catecholamines.儿茶酚胺释放的突触前调节。

Pharmacol Rev. 1980 Dec;32(4):337-62.

Presynaptic receptors.突触前受体

Annu Rev Pharmacol Toxicol. 1981;21:7-30. doi: 10.1146/annurev.pa.21.040181.000255.

Functional characterization of central alpha-adrenoceptors by yohimbine diastereomers.育亨宾非对映体对中枢α-肾上腺素能受体的功能特性研究

Eur J Pharmacol. 1981 Mar 5;70(1):43-52. doi: 10.1016/0014-2999(81)90430-1.

Alpha-adrenoceptor-mediated modulation of 5-hydroxytryptamine release from rat brain cortex slices.α-肾上腺素能受体介导对大鼠脑皮质切片中5-羟色胺释放的调节。

Naunyn Schmiedebergs Arch Pharmacol. 1980 Aug;313(1):21-6. doi: 10.1007/BF00505800.

Inhibition of neuronal uptake reduces the presynaptic effects of clonidine but not of alpha-methylnoradrenaline on the stimulation-evoked release of 3H-noradrenaline from rat occipital cortex slices.抑制神经元摄取可降低可乐定对大鼠枕叶皮质切片刺激诱发的3H-去甲肾上腺素释放的突触前效应，但对α-甲基去甲肾上腺素则无此作用。

Eur J Pharmacol. 1980 Jun 13;64(2-3):143-55. doi: 10.1016/0014-2999(80)90037-0.

Noradrenaline inhibits depolarization-induced 3H-serotonin release from slices of rat hippocampus.去甲肾上腺素抑制大鼠海马切片中去极化诱导的3H-5-羟色胺释放。

Eur J Pharmacol. 1980 May 2;63(2-3):179-82. doi: 10.1016/0014-2999(80)90441-0.

Preferential blockade of alpha 1-adrenoceptors in the rabbit pulmonary artery by derivatives of beta-phenylethylamine chemically related to BE 2254 (heat).与BE 2254（热）化学相关的β-苯乙胺衍生物对兔肺动脉α1-肾上腺素能受体的优先阻断作用。

J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):12-8. doi: 10.1097/00005344-198301000-00002.

Naunyn Schmiedebergs Arch Pharmacol. 1983 Mar;322(2):121-8. doi: 10.1007/BF00512384.

alpha-Adrenoceptor-mediated inhibition of noradrenaline release in rabbit brain cortex slices. Receptor properties and role of the biophase concentration of noradrenaline.α-肾上腺素能受体介导的兔脑皮质切片中去甲肾上腺素释放的抑制作用。受体特性及去甲肾上腺素生物相浓度的作用。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Apr;319(1):71-7. doi: 10.1007/BF00491481.

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