Rolly G
Acta Anaesthesiol Belg. 1977;28(4):233-44.
In 17 patients, the reversal by naloxone of a short duration narcotic anesthesia done for neuroradiology, was studied. Neuroleptanalgesic technique comprised d-hydrobenzperidol (5-10 mg) and fentanyl (+/- 0.4 mg) after barbiturate induction, and curarization with pancuronium, reversed by neostigmine. In group A 2 microgram/kg naloxone I.V. was given and 1 microgram/kg I.M. 30 min. later and in group B 1 micrometer/kg I.V. and 30 min. later 0.5 micrometer/kg. Reversal of narcotic depression was good and well maintained for 60 min. in both groups, as evidenced by respiratory rate, respiratory minute volume, pHa, PaCO2. Marginal temporarily cardiovascular stimulation occurred with arousal. Tolerance was good. It is concluded that antagonisation of respiratory depression due to narcotic anesthesia is possible with small titrated dosis of naloxone.
对17例因神经放射学检查而接受短时间麻醉的患者，研究了纳洛酮对其麻醉作用的逆转情况。神经安定镇痛技术包括在巴比妥类药物诱导后使用氢溴酸苯哌利多（5 - 10毫克）和芬太尼（±0.4毫克），并用潘库溴铵进行肌松，用新斯的明逆转。A组静脉注射2微克/千克纳洛酮，30分钟后肌肉注射1微克/千克；B组静脉注射1微克/千克，30分钟后注射0.5微克/千克。两组患者的麻醉抑制逆转效果良好，且在60分钟内维持良好，呼吸频率、每分通气量、动脉血pH值、动脉血二氧化碳分压均证明了这一点。苏醒时出现轻微的暂时性心血管刺激。耐受性良好。结论是，小剂量滴定的纳洛酮可逆转麻醉性麻醉所致的呼吸抑制。
