不可逆的鸟氨酸脱羧酶抑制剂α-二氟甲基鸟氨酸对γ-谷氨酰转移酶阳性灶形成的影响。
Effect of alpha-difluoromethylornithine, an irreversible ornithine decarboxylase inhibitor, on formation of GGTase-positive foci.
作者信息
Savage R E, Herren S, Pereira M A
出版信息
J Toxicol Environ Health. 1983 Apr-Jun;11(4-6):637-41. doi: 10.1080/15287398309530373.
The importance of the induction of ornithine decarboxylase to the development of GGTase foci is examined in the classic initiation-promotion assay. This was accomplished by examining the complete foci system in the presence and absence of alpha-DFMO, an irreversible inhibitor of ornithine decarboxylase, at concentrations capable of inhibiting both phenobarbital stimulated and control levels of the enzyme. Although the hepatic enzyme was inhibited by the alpha-DFMO, there was no decrease in the progression of formation of the GGTase foci.
在经典的启动-促进试验中，研究了鸟氨酸脱羧酶的诱导对γ-谷氨酰转肽酶（GGTase）病灶形成的重要性。这是通过在存在和不存在α-二氟甲基鸟氨酸（α-DFMO）（鸟氨酸脱羧酶的不可逆抑制剂）的情况下检查完整的病灶系统来实现的，α-DFMO的浓度能够抑制苯巴比妥刺激的和对照水平的该酶。尽管α-DFMO抑制了肝脏中的这种酶，但GGTase病灶形成的进展并未减少。
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