Kadmon D, Heston W D, Lazan D W, Fair W R
J Nucl Med. 1982 Nov;23(11):998-1002.
We studied the effect of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, on putrescine uptake by the rat prostate. Using C-14 putrescine, we found a several-fold increase in uptake by both the dorsal and ventral prostates of DFMO-pretreated intact animals, compared with untreated controls. When previously castrated animals were treated with a combination of testosterone and DFMO, the prostatic uptake of exogenously administered C-14 putrescine increased more than tenfold. Under these conditions, DFMO enhanced the uptake by the prostate to a greater extent than by any other tissue studies.
我们研究了鸟氨酸脱羧酶的不可逆抑制剂α-二氟甲基鸟氨酸（DFMO）对大鼠前列腺摄取腐胺的影响。使用C-14标记的腐胺，我们发现，与未处理的对照组相比，经DFMO预处理的完整动物的背侧和腹侧前列腺的摄取量增加了几倍。当先前阉割的动物用睾酮和DFMO联合处理时，外源性给予的C-14腐胺的前列腺摄取量增加了十多倍。在这些条件下，DFMO比其他任何研究的组织都更能增强前列腺的摄取。
