两种用于脑和肝组织中氧消耗的非经典模型的比较。

A comparison of two nonclassical models for oxygen consumption in brain and liver tissue.

作者信息

Buerk D G, Saidel G M

出版信息

Adv Exp Med Biol. 1977;94:225-32. doi: 10.1007/978-1-4684-8890-6_31.

Abstract

Experimentally observed steady-state pO2 profiles in tissue slices can be described by a Michaelis-Menten oxygen consumption model. Calculated values for Km = 0., torr in brain tissue, and Km = 2.2 torr in liver tissue are two orders of magnitude higher than Km values determined from mitochondrial suspensions. Brain tissue has a higher metabolic rate and higher affinity for oxygen than liver tissue.

摘要

实验观察到的组织切片中的稳态氧分压分布可用米氏耗氧模型来描述。脑组织中计算得出的米氏常数（Km）值为0. 托，肝组织中Km值为2.2托，这两个值比从线粒体悬浮液中测定的Km值高两个数量级。脑组织比肝组织具有更高的代谢率和对氧的更高亲和力。