Płaźnik A, Danysz W, Kostowski W, Bidziński A, Hauptmann M
Pharmacol Biochem Behav. 1983 Jul;19(1):27-32. doi: 10.1016/0091-3057(83)90306-4.
The effects of microinjections of adrenergic receptors agonists and antagonists into the median raphe nucleus (MR) on behavior and serotonin (5HT) metabolism was examined in rats. Administration of adrenergic alpha 1 and alpha 2 receptor agonists (noradrenaline, phenylephrine, clonidine) produced behavioral excitation in the open field test and a tendency to decrease the forebrain 5-hydroxyindolo-acetic acid (5HIAA) concentration. Opposite effects were seen after microinjection of adrenergic alpha receptor antagonists (phenoxybenzamine, phentolamine but not yohimbine). A significant negative correlation was found between the effects on locomotor activity and 5HIAA levels in these rats. No effect was present after injection of beta receptor agonist salbutamol or antagonist propranolol. It is suggested that noradrenaline released from noradrenergic terminals in the MR tonically inhibits the activity of 5HT neurons thus producing symptoms of 5HT deficiency and that this action of noradrenaline is probably limited to the effects on alpha 1 but not alpha 2 nor beta adrenoceptors in this brain region.
研究了向大鼠中缝正中核（MR）微量注射肾上腺素能受体激动剂和拮抗剂对行为及5-羟色胺（5HT）代谢的影响。给予肾上腺素能α1和α2受体激动剂（去甲肾上腺素、苯肾上腺素、可乐定）后，在旷场试验中产生行为兴奋，并使前脑5-羟吲哚乙酸（5HIAA）浓度有降低趋势。微量注射肾上腺素能α受体拮抗剂（酚苄明、酚妥拉明，但育亨宾无此作用）后则出现相反效应。在这些大鼠中，发现对运动活动的影响与5HIAA水平之间存在显著负相关。注射β受体激动剂沙丁胺醇或拮抗剂普萘洛尔后无效应。提示从中缝正中核去甲肾上腺素能终末释放的去甲肾上腺素可紧张性抑制5HT能神经元的活动，从而产生5HT缺乏症状，且去甲肾上腺素的这一作用可能仅限于对该脑区α1受体而非α2及β肾上腺素能受体的影响。
