Murray K, Feneley R C
Urology. 1983 Sep;22(3):332-4. doi: 10.1016/s0090-4295(83)80033-8.
The effect of opiate analgesics (omnopon, pethidine, pentazocine) on the urethral mucosal sensitivity threshold in 37 patients, and of the potent opiate/opioid antagonist naloxone on 10 volunteers is described. Omnopon and pentazocine caused a significant decrease in sensitivity (p less than 0.02) and naloxone caused a significant increase in sensitivity (p less than 0.02). The results confirm a role for the endogenous opioids in modulating urethral sensitivity, and the implications of this are discussed.
本文描述了阿片类镇痛药（阿片全碱、哌替啶、喷他佐辛）对37例患者尿道黏膜敏感阈值的影响，以及强效阿片/阿片样物质拮抗剂纳洛酮对10名志愿者的影响。阿片全碱和喷他佐辛使敏感度显著降低（p<0.02），纳洛酮使敏感度显著升高（p<0.02）。结果证实内源性阿片样物质在调节尿道敏感度方面发挥作用，并对其影响进行了讨论。
