Heinrich R, Acker H
Adv Exp Med Biol. 1977;94:517-23. doi: 10.1007/978-1-4684-8890-6_69.
During normovolaemic haemodilution with Macrodex (R), the basic respiratory activity is unchanged, while the ventilatory responses to hypoxia and hypercapnia generally decrease. The PGO2 in the cat carotid body remains constant down to an Hk of 10% to 15% and then decreases. This confirms the suggestion of Acker and Lübbers (1976) that increased plasma flow through the carotid body does not influence the oxygen supply to this organ, despite variations of both oxygen transport capacity and haemoglobin concentration. The fine structure of the carotid body is partly destroyed by haemodilution with Macrodex (R) and this could account for the impaired chemoreception.
在用右旋糖酐(Macrodex)进行正常血容量血液稀释期间,基本呼吸活动保持不变,而对低氧和高碳酸血症的通气反应通常会降低。猫颈动脉体中的混合静脉血氧分压(PGO2)在血细胞比容(Hk)降至10%至15%之前保持恒定,然后降低。这证实了阿克(Acker)和吕伯斯(Lübbers)(1976年)的观点,即尽管氧运输能力和血红蛋白浓度都有所变化,但流经颈动脉体的血浆流量增加并不会影响该器官的氧气供应。用右旋糖酐(Macrodex)进行血液稀释会部分破坏颈动脉体的精细结构,这可能是化学感受受损的原因。