Agnati L F, Fuxe K, Calza L, Zini I, Benefenati F, Farabegoli C, Goldstein M
Acta Physiol Scand. 1983 May;118(1):27-34. doi: 10.1111/j.1748-1716.1983.tb07236.x.
Chronic i.p. treatment with 1-dopa-carbidopa for 3 weeks in hemitransected male rats leads on one hand to tolerance to 1-dopa induced turning behaviour and on the other hand to behavioural and biochemical signs of dopamine (DA receptor supersensitivity on the intact side. Thus, the apomorphine induced ipsilateral turning behaviour is enhanced and the KD values of the 3H-spiperone binding sites linked to DA receptors of the D2 type on the intact, but not on the denervated side are reduced by 40%. However, the number of 3H-spiperone binding sites is reduced by 20% in striatal membranes on the intact side after this type of treatment. Therefore, chronic treatment with a catecholamine (CA) precursor leads to selective adaptive changes at intact striatal DA synapses with certain signs of the expected development of DA receptor subsensitivity, but above all with signs of paradoxical development of DA receptor supersensitivity. A hypothesis is introduced to explain these results.
在半横断的雄性大鼠中，连续3周腹腔注射左旋多巴-卡比多巴进行慢性治疗，一方面会导致对左旋多巴诱导的旋转行为产生耐受性，另一方面会出现行为和生化方面多巴胺（DA）受体超敏的迹象，即完整侧出现超敏现象。因此，阿扑吗啡诱导的同侧旋转行为增强，与完整侧（而非去神经侧）D2型DA受体相连的3H-螺哌隆结合位点的KD值降低了40%。然而，经过这种类型的治疗后，完整侧纹状体膜上3H-螺哌隆结合位点的数量减少了20%。因此，用儿茶酚胺（CA）前体进行慢性治疗会导致完整纹状体DA突触发生选择性适应性变化，出现一些预期的DA受体亚敏化发展迹象，但最重要的是出现了DA受体超敏化的矛盾发展迹象。本文引入了一个假说来解释这些结果。
