Shin Y K, Svinareff P, Schmitt-Jubeau H, Schmitt H
Arch Int Pharmacodyn Ther. 1983 Jul;264(1):73-81.
The effects of quipazine on blood pressure in pithed rats and the mechanism of the pressor response were studied. Quipazine and 5 HT produced an abrupt increase in blood pressure. The pressor responses were reduced by phentolamine and phenoxybenzamine. The noradrenaline depletion induced by pretreatment with reserpine significantly reduced the pressor effects of quipazine. Methysergide, at a dose which did not alter pressor responses to noradrenaline, reduced the increase in blood pressure induced by quipazine and 5 HT. These results suggest that quipazine activates 5-hydroxytryptaminergic receptors stimulating the release of noradrenaline. The effect observed in reserpinized rats can be explained by the interconnection of 5-hydroxytryptamine receptors and alpha-adrenoceptors.
研究了喹哌嗪对脊髓横断大鼠血压的影响及其升压反应的机制。喹哌嗪和5-羟色胺可使血压突然升高。酚妥拉明和酚苄明可减弱升压反应。利血平预处理所致的去甲肾上腺素耗竭显著降低了喹哌嗪的升压作用。麦角新碱在不改变对去甲肾上腺素升压反应的剂量下，可减弱喹哌嗪和5-羟色胺所致的血压升高。这些结果提示，喹哌嗪激活5-羟色胺能受体，刺激去甲肾上腺素释放。在利血平化大鼠中观察到的效应可通过5-羟色胺受体与α-肾上腺素能受体的相互联系来解释。
