茚萘洛尔长期给药对高血压大鼠的影响。

Effects of prolonged administration of indenolol in hypertensive rats.

作者信息

Kato H, Kurihara J, Takata Y, Kunugi H, Miyajima Y

出版信息

Arch Int Pharmacodyn Ther. 1983 Jul;264(1):82-95.

Abstract

The effects of 4-week administration and subsequent 2-week withdrawal of indenolol, 50 mg/kg/day p.o., were investigated in spontaneously hypertensive rats (SHR), renal hypertensive rats (RHR) and DOCA-salt hypertensive rats (DHR) at established stage, and compared with those of propranolol, 100 mg/kg/day p.o. Indenolol and propranolol caused a marked decrease in heart rate in SHR, RHR and DHR without showing a pronounced antihypertensive activity. Both drugs did not affect the body weight gain in RHR and DHR. On the other hand, the drugs suppressed the body weight gain in SHR, which recovered during 2-week withdrawal period. Weights of the heart, kidney, liver, spleen and adrenals were not affected by the drugs. Indenolol and propranolol markedly lowered the plasma renin activity (PRA) in SHR, RHR and DHR. PRA in RHR and DHR recovered to the control level during 2-week withdrawal period, while that in SHR did not. The results indicate that indenolol produces essentially the same effect as propranolol in SHR, RHR and DHR. Prolonged administration of indenolol to SHR, RHR and DHR with established hypertension produces a marked suppression of cardiac performance and PRA with showing antihypertensive activity.

摘要

研究了口服给予茚萘洛尔（50mg/kg/天）4周并随后停药2周对处于高血压确立期的自发性高血压大鼠（SHR）、肾性高血压大鼠（RHR）和去氧皮质酮盐性高血压大鼠（DHR）的影响，并与口服普萘洛尔（100mg/kg/天）的效果进行比较。茚萘洛尔和普萘洛尔可使SHR、RHR和DHR的心率显著降低，但未表现出明显的降压活性。两种药物对RHR和DHR的体重增加均无影响。另一方面，这两种药物抑制了SHR的体重增加，在停药2周期间体重恢复。心脏、肾脏、肝脏、脾脏和肾上腺的重量不受药物影响。茚萘洛尔和普萘洛尔显著降低了SHR、RHR和DHR的血浆肾素活性（PRA）。RHR和DHR的PRA在停药2周期间恢复至对照水平，而SHR的PRA则未恢复。结果表明，茚萘洛尔在SHR、RHR和DHR中产生的作用与普萘洛尔基本相同。对已患高血压的SHR、RHR和DHR长期给予茚萘洛尔可显著抑制心脏功能和PRA，但未表现出降压活性。