促性腺激素释放激素对信使核糖核酸多聚腺苷酸化的抑制作用。
Inhibition of polyadenylation of mRNA by gonadotropin releasing hormone.
作者信息
Raju V S, Reddy P R
出版信息
Biochem Biophys Res Commun. 1983 Sep 15;115(2):451-5. doi: 10.1016/s0006-291x(83)80165-x.
The mechanism of extra pituitary inhibitory action of gonadotropin releasing hormone (GnRH) was investigated. Simultaneous injection of GnRH caused dose dependent inhibition of dihydrotestosterone (DHT) induced poly(A) polymerase in the ventral prostate of rat. In addition injection of GnRH to DHT treated animals caused reduced incorporation of 3H-uridine into poly(A)+ mRNA. Since poly(A) segment is known to help in translation of mRNA, it is possible that the inhibitory effect of GnRH is due to the inhibition of polyadenylation of mRNA.
研究了促性腺激素释放激素（GnRH）垂体外抑制作用的机制。同时注射GnRH可导致大鼠腹侧前列腺中二氢睾酮（DHT）诱导的多聚腺苷酸聚合酶呈剂量依赖性抑制。此外，向经DHT处理的动物注射GnRH会导致3H-尿苷掺入多聚腺苷酸（poly(A)）+ mRNA的量减少。由于已知多聚腺苷酸片段有助于mRNA的翻译，因此GnRH的抑制作用可能是由于抑制了mRNA的多聚腺苷酸化。
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