慢性气流阻塞患者肺循环对口服吡布特罗的反应。
Response of pulmonary circulation to oral pirbuterol in chronic airflow obstruction.
作者信息
Peacock A, Busst C, Dawkins K, Denison D M
出版信息
Br Med J (Clin Res Ed). 1983 Oct 22;287(6400):1178-80. doi: 10.1136/bmj.287.6400.1178.
Abstract
The effects of the oral beta agonist pirbuterol on pulmonary haemodynamics and gas exchange were studied in nine patients with severe irreversible airflow obstruction and moderate arterial hypoxaemia. After administration of 15 mg pirbuterol pulmonary vascular resistance fell by 19% but cardiac output rose by 24%, so that pulmonary arterial pressure showed no significant change. Systemic arterial oxygen pressure fell by 7%, limiting the rise in oxygen delivery to 21%. All changes were significant at the 2% level. These results show that pirbuterol dilates the pulmonary bed at the cost of a slight worsening of gas exchange, which is compensated by an independent rise in blood flow.
摘要
对9例患有严重不可逆气流阻塞和中度动脉血氧不足的患者，研究了口服β受体激动剂吡布特罗对肺血流动力学和气体交换的影响。给予15毫克吡布特罗后，肺血管阻力下降了19%，但心输出量增加了24%，因此肺动脉压无显著变化。体动脉血氧分压下降了7%，使氧输送量的增加限制在21%。所有变化在2%水平均具有显著性。这些结果表明，吡布特罗使肺血管床扩张，但以气体交换稍有恶化为代价，而这可通过血流的独立增加得到代偿。
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