Effect of silver on sodium transport across toad skin.

Silver attenuated the insulin-induced short-circuit current and transmural potential difference. Silver diminished the ethacrynic acid-induced short-circuit current and transmural potential difference. Ouabain inhibited short-circuit current and transmural potential difference, equivalently, whether silver was present or not. The low concentration silver-induced short-circuit current is carried by a net active sodium transfer from the outside to the inside bathing solution.