Rainsbury R M, Ott R J, Westwood J H, Kalirai T S, Coombes R C, McCready V R, Neville A M, Gazet J C
Lancet. 1983 Oct 22;2(8356):934-8. doi: 10.1016/s0140-6736(83)90452-x.
The ability of a radiolabelled monoclonal antibody, LICR-LON-M8 (M8), to locate metastatic breast carcinomas has been investigated. The scans generated by M8, either when labelled with radioiodine, or when conjugated with diethylenetriamine-pentaacetic acid (DTPA) and labelled with radioactive indium (111In), have been compared with X-rays and 99mTc-methyl diphosphonate (MDP) bone scans. All 10 patients with skeletal metastases had positive 111In-DTPA-M8 scans and the overall correlation with X-rays and MDP scans was good but varied with the region studied. By contrast, radioiodinated M8 did not detect metastases at any site. The discrepancies between 111In-DTPA-M8 images and conventional techniques may be related to the different stages in the evolution and development of the lesion at which the various techniques detect bone metastases.
已对放射性标记的单克隆抗体LICR-LON-M8（M8）定位转移性乳腺癌的能力进行了研究。将用放射性碘标记的M8，或与二乙烯三胺五乙酸（DTPA）偶联并用放射性铟（111In）标记的M8所生成的扫描图像，与X射线和99mTc-亚甲基二膦酸盐（MDP）骨扫描图像进行了比较。所有10例有骨转移的患者111In-DTPA-M8扫描均为阳性，与X射线和MDP扫描的总体相关性良好，但因研究区域而异。相比之下，放射性碘化M8在任何部位均未检测到转移灶。111In-DTPA-M8图像与传统技术之间的差异可能与各种技术检测骨转移灶时病变演变和发展的不同阶段有关。
