Schifferli J A, Peters D K
Lancet. 1983 Oct 22;2(8356):957-9. doi: 10.1016/s0140-6736(83)90464-6.
The role of the components of the complement classical pathway in maintaining antigen-antibody complexes in solution has implications for the understanding of the pathophysiology of complement-deficiency syndromes. It is proposed that this mechanism may normally keep immune complexes soluble for a sufficient time for their safe elimination by the mononuclear phagocyte system. When an early component of the classical pathway is deficient or depleted antigen-antibody complexes would be more likely to precipitate at or near their site of formation and lead to immunologically mediated inflammation. This hypothesis is supported by the predisposition to immune-complex diseases of patients with genetically determined deficiencies of components of the classical pathway.
补体经典途径各成分在维持溶液中的抗原-抗体复合物方面所起的作用，对于理解补体缺陷综合征的病理生理学具有重要意义。有人提出，这一机制通常可使免疫复合物在足够长的时间内保持可溶状态，以便单核吞噬细胞系统将其安全清除。当经典途径的早期成分缺乏或耗竭时，抗原-抗体复合物更有可能在其形成部位或附近沉淀，并引发免疫介导的炎症。这一假说得到了经典途径成分存在基因决定缺陷的患者易患免疫复合物疾病的支持。
