Smith U
Acta Med Scand Suppl. 1983;672:41-4. doi: 10.1111/j.0954-6820.1983.tb01612.x.
Adrenergic receptors are ubiquitous and mediate several important effects involving lipid metabolism. Thus, beta-adrenergic stimulation increases lipolysis and inhibits the activity of the lipoprotein lipase. In contrast, alpha-adrenergic stimulation inhibits fat cell lipid mobilisation. Unexpectedly, beta-adrenergic blockade increases plasma triglyceride levels and tends to lower the high density lipoprotein (HDL-cholesterol). These effects seem to be prevented or attenuated by concomitant alpha-blockade. Possible mechanisms for the adrenergic effect on lipid metabolism are reviewed.
肾上腺素能受体广泛存在，并介导涉及脂质代谢的多种重要作用。因此，β-肾上腺素能刺激可增加脂肪分解并抑制脂蛋白脂肪酶的活性。相比之下，α-肾上腺素能刺激可抑制脂肪细胞的脂质动员。出乎意料的是，β-肾上腺素能阻断会增加血浆甘油三酯水平，并倾向于降低高密度脂蛋白（HDL-胆固醇）。这些作用似乎可通过同时进行的α-阻断来预防或减弱。本文综述了肾上腺素能对脂质代谢作用的可能机制。
