截瘫和四肢瘫患者的血脂谱：性别差异
Lipid profiles of persons with paraplegia and tetraplegia: sex differences.
作者信息
Schmid Andreas, Knöebber Judith, Vogt Stefan, König Daniel, Deibert Peter, Bültermann Dirk, Heinrich Lothar, Baumstark Manfred W, Berg Aloys, Storch Max-Jürgen
机构信息
AsuA Medical Consulting, Freiburg, Germany.
出版信息
J Spinal Cord Med. 2008;31(3):285-9. doi: 10.1080/10790268.2008.11760724.
BACKGROUND/OBJECTIVE: To examine the lipoprotein profiles of men and women with paraplegia and tetraplegia. Impairment of the sympathetic nervous system (dependent on the level of injury) and the extent of physical capacity and activity were correlated with the lipid profile in men with spinal cord injury (SCI). Sex-related differences of the lipoprotein profiles could be found in nondisabled and premenopausal women with SCI mainly because of the different effects of sexual hormones.
METHODS
Lipoprotein profiles of 112 participants with SCI (32 premenopausal women, 80 men) were analyzed and correlated to sex, lesion level, and physical performance capacity.
RESULTS
Women with tetraplegia or paraplegia showed significantly higher levels of high-density lipoprotein and lower ratios of total cholesterol to high-density lipoprotein-cholesterol compared with men with corresponding lesion levels, without a difference in peak oxygen consumption. Concentrations of very-low-density lipoproteins were lower in women with paraplegia than in men with paraplegia; no differences were found in total cholesterol, low-density lipoprotein-cholesterol, and triglycerides. Sex-independent elevations in total cholesterol and low-density lipoprotein-cholesterol were associated with paraplegia, and sex-independent elevations in triglyceride levels were associated with tetraplegia.
CONCLUSIONS
Persons with SCI showed sex-related differences in their lipoprotein profiles. Independent of physical fitness, the lipoprotein profile of premenopausal women with SCI did not exhibit the adverse lipoprotein characteristics observed in men with SCI, probably because of the influence of sexual hormones independent of lesion level.
背景/目的：研究截瘫和四肢瘫男性与女性的脂蛋白谱。交感神经系统的损伤（取决于损伤水平）以及身体能力和活动程度与脊髓损伤（SCI）男性的血脂谱相关。在未残疾和绝经前的SCI女性中可发现脂蛋白谱的性别差异，主要是由于性激素的不同作用。
方法
分析了112名SCI参与者（32名绝经前女性，80名男性）的脂蛋白谱，并将其与性别、损伤水平和身体运动能力相关联。
结果
与相应损伤水平的男性相比，四肢瘫或截瘫女性的高密度脂蛋白水平显著更高，总胆固醇与高密度脂蛋白胆固醇的比率更低，而峰值耗氧量无差异。截瘫女性的极低密度脂蛋白浓度低于截瘫男性；总胆固醇、低密度脂蛋白胆固醇和甘油三酯无差异。截瘫与总胆固醇和低密度脂蛋白胆固醇的性别无关升高有关，四肢瘫与甘油三酯水平的性别无关升高有关。
结论
SCI患者的脂蛋白谱存在性别差异。独立于身体素质，绝经前SCI女性的脂蛋白谱未表现出SCI男性中观察到的不良脂蛋白特征，这可能是由于性激素的影响，与损伤水平无关。
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