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[谷氨酸脱氢酶在酗酒者生物学检测中的作用]

[Role of glutamate dehydrogenase in the biological detection of excessive drinkers].

作者信息

Schellenberg F, Weill J, Lamy J N

出版信息

Ann Biol Clin (Paris). 1983;41(4):255-62.

PMID:6139049
Abstract

384 hospitalized patients of both sexes were classified into drinkers and non-drinkers according to clinical criteria. On admission, we measured four blood parameters : glutamate dehydrogenase, gamma glutamyl transferase, aspartate aminotransferase and the mean corpuscular volume. the discriminating power of these laboratory parameters was evaluated by descriptive statistical tests and by the determination of their positive and negative predictive value. Glutamate dehydrogenase appears to present a sensitivity almost equivalent to that of gamma glutamyl transferase and a better specificity : this results in a more positive predictive value. The two other laboratory parameters are less discriminating.

摘要

384名住院患者根据临床标准分为饮酒者和非饮酒者。入院时,我们测量了四项血液参数:谷氨酸脱氢酶、γ-谷氨酰转移酶、天冬氨酸转氨酶和平均红细胞体积。通过描述性统计检验及其阳性和阴性预测值的测定来评估这些实验室参数的鉴别能力。谷氨酸脱氢酶似乎具有与γ-谷氨酰转移酶几乎相当的敏感性和更好的特异性:这导致更高的阳性预测值。其他两项实验室参数的鉴别能力较弱。

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引用本文的文献

1
Adaptation of methods for glutamate dehydrogenase and alcohol dehydrogenase activities to a centrifugal analyser: assessment of their clinical use in anoxic states of the liver.谷氨酸脱氢酶和乙醇脱氢酶活性检测方法在离心分析仪上的适配:对其在肝脏缺氧状态下临床应用的评估
J Clin Pathol. 1987 Oct;40(10):1240-6. doi: 10.1136/jcp.40.10.1240.