蜂毒明肽对豚鼠α-肾上腺素能受体介导的血浆钾变化的影响。
Effects of apamin on alpha-adrenoceptor-mediated changes in plasma potassium in guinea-pigs.
作者信息
Coats R A
出版信息
Br J Pharmacol. 1983 Nov;80(3):573-80. doi: 10.1111/j.1476-5381.1983.tb10731.x.
Abstract
An intravenous K+-sensitive electrode has been used to monitor plasma [K+] changes induced by adrenaline (1.4-6.8 micrograms kg-1) and amidephrine (14-340 micrograms kg-1) in anaesthetized guinea-pigs. A biphasic response consisting of an initial increase in [K+] followed, within 1 min, by a fall below baseline was observed with both agonists. Apamin (0.4-40 micrograms kg-1) reduced the hyperkalaemic phase of the response to amidephrine in a dose-related, non-competitive manner. The response to adrenaline was also reduced but to a lesser extent. Apamin caused little or no reduction of the hypokalaemic phase of the response to either agonist.
摘要
已使用静脉内钾敏感电极监测麻醉豚鼠体内由肾上腺素（1.4 - 6.8微克/千克）和去氧肾上腺素（14 - 340微克/千克）引起的血浆[K⁺]变化。两种激动剂均观察到双相反应，即[K⁺]先出现初始升高，随后在1分钟内降至基线以下。蜂毒明肽（0.4 - 40微克/千克）以剂量相关的非竞争性方式降低了对去氧肾上腺素反应的高钾血症期。对肾上腺素的反应也有所降低，但程度较小。蜂毒明肽对两种激动剂反应的低钾血症期几乎没有或没有降低作用。
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