Hosking D J, Campbell G A, Kemm J R, Cotton R E, Knight M E, Berryman R, Boyd R V
Lancet. 1983 Dec 3;2(8362):1290-2. doi: 10.1016/s0140-6736(83)91160-1.
Although osteomalacia is known to be common in some sections of the elderly population, the disease is often subclinical and there is uncertainty about the point at which treatment is necessary. Identification and treatment of osteomalacia are inseparably bound; the response of varying degrees of subclinical disease to treatment with vitamin D or alfacalcidol is described here. The response is assessed in relation to a simply derived reference range based on standard biochemical measurements together with a Jamshidi needle biopsy of the iliac crest. Although this technique does not define a truly normal range it identifies a treatable abnormality which could form the basis of further study of the problem of subclinical osteomalacia in the elderly.
尽管已知骨软化症在老年人群的某些群体中很常见，但该疾病往往是亚临床的，对于何时需要治疗尚不确定。骨软化症的识别与治疗紧密相连；本文描述了不同程度的亚临床疾病对维生素D或阿法骨化醇治疗的反应。基于标准生化测量以及髂嵴的Jamshidi针活检得出一个简单的参考范围，并据此评估反应。尽管该技术并未定义一个真正的正常范围，但它识别出了一种可治疗的异常情况，这可能为进一步研究老年人亚临床骨软化症问题奠定基础。
