生长激素释放因子刺激垂体前叶中的腺苷酸环化酶活性。
Growth hormone-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland.
作者信息
Labrie F, Gagné B, Lefèvre G
出版信息
Life Sci. 1983 Nov 28;33(22):2229-33. doi: 10.1016/0024-3205(83)90295-3.
Synthetic human pancreatic growth hormone-releasing factor (hpGRF)(1-40)-NH2 stimulates adenylate cyclase activity in rat anterior pituitary particulate fraction at an ED50 value of approximately 150 nM. GTP more than doubles the stimulatory effect of hpGRF and PGE2 on [32P] cyclic AMP formation. The present data show that hpGRF as well as PGE2, another potent stimulus of GH secretion, act at least partly, through GTP-dependent mechanisms in their coupling with adenylate cyclase.
合成的人胰腺生长激素释放因子（hpGRF）（1 - 40）-NH2 以约 150 nM 的半数有效剂量（ED50）刺激大鼠垂体前叶微粒体部分的腺苷酸环化酶活性。鸟苷三磷酸（GTP）使 hpGRF 和前列腺素 E2（PGE2）对[32P]环磷酸腺苷（cAMP）形成的刺激作用增加一倍以上。目前的数据表明，hpGRF 以及 PGE2（另一种强效的生长激素分泌刺激物）在与腺苷酸环化酶偶联时，至少部分通过依赖 GTP 的机制发挥作用。
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