Regunathan S, Sundaresan R
Life Sci. 1983 Dec 5;33(23):2277-82. doi: 10.1016/0024-3205(83)90260-6.
The incorporation of label from U14C glucose into glutamic acid, glutamine and GABA remained unaltered with the presence of lead acetate in the medium whereas tetraethyl lead (TEL) affected the incorporation in a characteristic manner in different regions of brain. Glucose uptake however was not influenced by TEL. Pyridoxal phosphate was found to reverse the effect of TEL on the incorporation especially in cerebellum and brainstem but with little effect in cerebral cortex. These findings suggest that the alterations in the GABA metabolism in TEL toxicity could be restored to some extent by pyridoxine in discrete brain areas.
在培养基中存在醋酸铅的情况下，14C 葡萄糖中的标记物掺入谷氨酸、谷氨酰胺和γ-氨基丁酸的情况保持不变，而四乙基铅（TEL）以一种特征性方式影响大脑不同区域的掺入。然而，葡萄糖摄取不受 TEL 影响。发现磷酸吡哆醛可逆转 TEL 对掺入的影响，尤其是在小脑和脑干，但对大脑皮层的影响很小。这些发现表明，在离散的脑区中，吡哆醇可以在一定程度上恢复 TEL 毒性中γ-氨基丁酸代谢的改变。
