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[克罗恩病的基础饮食]

[Basic diet in Crohn's disease].

作者信息

Stober B, Nützenadel W, Ullrich F

出版信息

Monatsschr Kinderheilkd. 1983 Oct;131(10):721-4.

PMID:6139745
Abstract

26 children with acute symptoms of Crohn's disease were treated with steroids and sulfasalazine (group A, 9 patients), with an elementary diet and sulfasalazine (group B, 10 patients), or with an elementary diet together with steroids and sulfasalazine (group C, 7 patients). Mean ages in each group were very similar, and treatment periods lasted 41.3 +/- 23.5, 37.4 +/- 12.7, and 36.9 +/- 9.1 days in group A, B and C, respectively. During treatment the sedimentation rate and the frequency of defecation decreased significantly in each group. Leucocytes in plasma fell to normal levels in group B but increased slightly in group A and C. Total proteins in plasma rose in group B and C but declined in group A. The body weight increased in each group but differences before and after treatment were significant only in group B and C. The findings suggest that children with active Crohn's disease may benefit from treatment with an elementary diet. Patients with an elementary diet showed significantly more weight gain than patients on steroid treatment. Besides nutritional effects a lower activity of inflammation was also noted.

摘要

26名患有克罗恩病急性症状的儿童接受了以下治疗:使用类固醇和柳氮磺胺吡啶治疗(A组,9例患者);采用要素饮食和柳氮磺胺吡啶治疗(B组,10例患者);或采用要素饮食并联合类固醇和柳氮磺胺吡啶治疗(C组,7例患者)。每组的平均年龄非常相似,A组、B组和C组的治疗期分别持续41.3±23.5天、37.4±12.7天和36.9±9.1天。治疗期间,每组的血沉和排便频率均显著下降。B组血浆中的白细胞降至正常水平,但A组和C组略有升高。B组和C组血浆总蛋白升高,而A组下降。每组体重均增加,但仅B组和C组治疗前后差异具有统计学意义。研究结果表明,患有活动性克罗恩病的儿童可能从要素饮食治疗中获益。采用要素饮食的患者体重增加明显多于接受类固醇治疗的患者。除营养作用外,还观察到炎症活性较低。

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