医院中雾化吸入β受体激动剂的剂量与给药方式
Dosage and delivery of nebulised beta agonists in hospital.
作者信息
Stainforth J N, Lewis R A, Tattersfield A E
出版信息
Thorax. 1983 Oct;38(10):751-4. doi: 10.1136/thx.38.10.751.
A questionnaire was sent to physicians with an interest in chest disease to determine the dose and method of delivery of nebulised beta agonists in hospital. All of the 67 physicians replying gave beta agonists by nebuliser, and all reported either salbutamol (72%) or terbutaline (10%) as the drug they prescribed most commonly (18% gave either drug). There was a fivefold difference in the dose of salbutamol they prescribed most commonly (range 2.5-12.5 mg, mode 5 mg), a 20 fold difference in the volume of diluent solution used (range 0.5-10 ml, mode 2 ml), and a 10 fold variation in the flow rates of gas driving the nebuliser (range 1-10 1/min, mode 4 1/min). There are therefore very large variations in the dose and method of delivery of beta agonists nebulised in hospital. Studies attempting to determine the optimum dose of beta agonist for use in a nebuliser need to take the type of nebuliser, diluent volume, and gas flow rate into account.
向对胸部疾病感兴趣的医生发放了一份调查问卷，以确定医院中雾化吸入β受体激动剂的剂量和给药方法。回复问卷的67位医生均通过雾化器给予β受体激动剂，且所有医生均报告他们最常开具的药物为沙丁胺醇（72%）或特布他林（10%）（18%开具这两种药物中的任意一种）。他们最常开具的沙丁胺醇剂量相差5倍（范围为2.5 - 12.5毫克，众数为5毫克），所使用稀释液的体积相差20倍（范围为0.5 - 10毫升，众数为2毫升），驱动雾化器的气体流速相差10倍（范围为1 - 10升/分钟，众数为4升/分钟）。因此，医院中雾化吸入β受体激动剂的剂量和给药方法存在非常大的差异。试图确定雾化器中使用β受体激动剂的最佳剂量的研究需要考虑雾化器的类型、稀释液体积和气体流速。
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