Influence of histamine-like drugs and immunomodulators on the spontaneous E rosette formation.

The effect of histamine, antihistamine drugs blocking H1 and H2 receptors and immunomodulatory drugs on RF cells was investigated. The test revealed the inhibitory effect of histamine and cimetidine on rosette formation and lack of any effect of antistine. It was found that the "suppressive" activity of histamine may be inhibited by the prior introduction to the culture of histamine H1 and H2-receptor antagonists. Besides, immunomodulatory drugs were observed to inhibit the above mentioned effect of histamine. The involvement of H1 and H2 receptors in the rosette formation was discussed and a suggestion as to the interaction of histamine and immunomodulators was put forward.