α-肾上腺素能受体拮抗剂对可乐定诱导的离体胰岛胰岛素分泌抑制作用的影响。
Effects of alpha-adrenoceptor antagonists on clonidine-induced inhibition of insulin secretion by isolated pancreatic islets.
作者信息
Langer J, Panten U, Zielmann S
出版信息
Br J Pharmacol. 1983 Jun;79(2):415-20. doi: 10.1111/j.1476-5381.1983.tb11014.x.
Abstract
The effects of clonidine, yohimbine, corynanthine and prazosin on glucose-induced insulin secretion by incubated or perifused mouse pancreatic islets were investigated. Clonidine (0.1 microM) inhibited glucose-induced insulin secretion alone and in the presence of yohimbine (0.1 microM), corynanthine (10 microM) or prazosin (1 microM). In higher concentrations, yohimbine (1-10 microM) antagonized the inhibitory effect of clonidine (0.1 microM) upon glucose-induced insulin secretion by incubated islets and by perifused islets. The results support the view that adrenergic inhibition of insulin secretion is mediated by alpha 2-adrenoceptors on pancreatic beta-cells.
摘要
研究了可乐定、育亨宾、柯楠碱和哌唑嗪对孵育或灌流的小鼠胰岛葡萄糖诱导胰岛素分泌的影响。可乐定（0.1微摩尔）单独以及在育亨宾（0.1微摩尔）、柯楠碱（10微摩尔）或哌唑嗪（1微摩尔）存在的情况下均抑制葡萄糖诱导的胰岛素分泌。在较高浓度下，育亨宾（1 - 10微摩尔）拮抗可乐定（0.1微摩尔）对孵育胰岛和灌流胰岛葡萄糖诱导胰岛素分泌的抑制作用。这些结果支持以下观点，即胰腺β细胞上的α2 - 肾上腺素能受体介导肾上腺素能对胰岛素分泌的抑制作用。
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