• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Recognition of insulin-releasing fuels by pancreatic B-cells: alpha-ketoisocaproic acid is an appropriate model compound to study the role of B-cell metabolism.

作者信息

Panten U, Biermann J, Graen W

出版信息

Mol Pharmacol. 1981 Jul;20(1):76-82.

PMID:6270540
Abstract
摘要

相似文献

1
Recognition of insulin-releasing fuels by pancreatic B-cells: alpha-ketoisocaproic acid is an appropriate model compound to study the role of B-cell metabolism.胰腺β细胞对胰岛素释放性燃料的识别：α-酮异己酸是研究β细胞代谢作用的合适模型化合物。
Mol Pharmacol. 1981 Jul;20(1):76-82.
2
Effects of 4-methyl-2-methylenevalerate, a non-metabolizable analogue of 2-ketoisocaproate, on insulin secretion and metabolism in ob/ob mouse pancreatic islets.4-甲基-2-亚甲基戊酸（2-酮异己酸的一种不可代谢类似物）对ob/ob小鼠胰岛中胰岛素分泌及代谢的影响
Experientia. 1982 Sep 15;38(9):1041-2. doi: 10.1007/BF01955354.
3
Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion.中性氨基酸和2-酮酸代谢对胰岛素分泌起始的信号功能。
J Biol Chem. 1982 Jun 25;257(12):6631-3.
4
Studies on the role of beta-cell metabolism in the insulinotropic effect of alpha-ketoisocaproic acid.β细胞代谢在α-酮异己酸促胰岛素分泌作用中的角色研究。
Biochim Biophys Acta. 1979 Dec 3;588(2):211-18. doi: 10.1016/0304-4165(79)90204-6.
5
2-ketoglutarate generation in pancreatic B-cell mitochondria regulates insulin secretory action of amino acids and 2-keto acids.胰腺β细胞线粒体中2-酮戊二酸的生成调节氨基酸和2-酮酸的胰岛素分泌作用。
Biosci Rep. 1986 Feb;6(2):163-9. doi: 10.1007/BF01115002.
6
O2 consumption by isolated pancreatic islets, as measured in a microincubation system with a Clark-type electrode.通过带有克拉克型电极的微量孵育系统测量分离的胰岛的氧气消耗。
Endocrinology. 1982 Nov;111(5):1595-600. doi: 10.1210/endo-111-5-1595.
7
Comparison of alpha-ketoisocaproic acid and glucose in rats: effects on insulin and somatostatin release and on islet cAMP content.大鼠体内α-酮异己酸与葡萄糖的比较：对胰岛素和生长抑素释放以及胰岛环磷酸腺苷含量的影响。
Mol Cell Endocrinol. 1978 Jun;11(1):51-61. doi: 10.1016/0303-7207(78)90032-1.
8
Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.在无营养物质的情况下，用磺脲类药物预处理的小鼠胰岛中，葡萄糖诱导的胰岛素分泌放大作用的选择性丧失。
Diabetologia. 2005 Dec;48(12):2563-6. doi: 10.1007/s00125-005-0030-5. Epub 2005 Nov 11.
9
Effect of L-asparaginase on insulin secretion from isolated rat islets of Langerhans.L-天冬酰胺酶对分离的大鼠胰岛胰岛素分泌的影响。
Horm Res. 1991;35(3-4):155-60. doi: 10.1159/000181893.
10
Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets.L-亮氨酸和α-酮异己酸诱导灌流分离胰岛释放胰岛素的机制研究。
Diabetologia. 1974 Apr;10(2):149-54. doi: 10.1007/BF01219672.

引用本文的文献

1
Coincidence of early glucose-induced depolarization with lowering of cytoplasmic Ca2+ in mouse pancreatic beta-cells.小鼠胰腺β细胞中早期葡萄糖诱导的去极化与细胞质Ca2+降低的巧合。
J Physiol. 1995 Jun 15;485 ( Pt 3)(Pt 3):607-17. doi: 10.1113/jphysiol.1995.sp020756.
2
Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue.胰腺β细胞线粒体中能量代谢对胰岛素分泌的调节。使用不可代谢亮氨酸类似物的研究。
Biochem J. 1984 Apr 1;219(1):189-96. doi: 10.1042/bj2190189.
3
Effects of alpha-adrenoceptor antagonists on clonidine-induced inhibition of insulin secretion by isolated pancreatic islets.
α-肾上腺素能受体拮抗剂对可乐定诱导的离体胰岛胰岛素分泌抑制作用的影响。
Br J Pharmacol. 1983 Jun;79(2):415-20. doi: 10.1111/j.1476-5381.1983.tb11014.x.
4
Regulation of energy metabolism in pancreatic islets by glucose and tolbutamide.葡萄糖和甲苯磺丁脲对胰岛能量代谢的调节作用。
Diabetologia. 1986 Sep;29(9):648-54. doi: 10.1007/BF00869265.
5
Glucose both inhibits and stimulates insulin secretion from isolated pancreatic islets exposed to maximally effective concentrations of sulfonylureas.葡萄糖既能抑制也能刺激分离的胰岛分泌胰岛素，这些胰岛暴露于最大有效浓度的磺脲类药物中。
Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):459-62. doi: 10.1007/BF00172128.
6
Effects of isoprenaline and glucagon on insulin secretion from pancreatic islets.异丙肾上腺素和胰高血糖素对胰岛胰岛素分泌的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):299-304. doi: 10.1007/BF00501884.
7
The dihydropyridine derivative, Bay K 8644, enhances insulin secretion by isolated pancreatic islets.二氢吡啶衍生物Bay K 8644可增强分离的胰岛分泌胰岛素的能力。
Naunyn Schmiedebergs Arch Pharmacol. 1985 Jan;328(3):351-3. doi: 10.1007/BF00515566.