Borea P A, Supavilai P, Karobath M
Brain Res. 1983 Dec 5;280(2):383-6. doi: 10.1016/0006-8993(83)90072-0.
Flunitrazepam, a benzodiazepine agonist increases, and DMCM, an inverse agonist decreases the stimulation by etazolate or pentobarbital of [3H] muscimol binding to membranes of rat cerebral cortex. Ro 15-1788 has no marked effects but antagonizes the action of both flunitrazepam and DMCM. The investigation of several drugs acting on benzodiazepine receptors on etazolate enhancement of [3H] muscimol binding suggests that their receptor interaction reflects a spectrum from agonists to inverse agonists.
氟硝西泮，一种苯二氮䓬类激动剂，可增强[3H]蝇蕈醇与大鼠大脑皮层膜结合的作用，而DMCM，一种反向激动剂，则可减弱依托唑啉或戊巴比妥对其的刺激作用。Ro 15-1788无明显作用，但可拮抗氟硝西泮和DMCM的作用。对几种作用于苯二氮䓬受体的药物在依托唑啉增强[3H]蝇蕈醇结合方面的研究表明，它们与受体的相互作用反映了从激动剂到反向激动剂的一系列情况。
