Abe T, Kawai N
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;76(2):221-5.
In the experiment of electrocardiogram, the crude venom of giant hornet (Vespa mandarinia) showed cardioactive effects on rat heart. The heart rate was accelerated within 5 min after injection of the venom intraperitoneally, then the heart beat was blocked, resulting in conduction delay. The cardioactive constituent was separated into two components by gel filtration. One which was high molecular species such as protein showed complete atrioventricular block. Another component, having a low molecular weight, was fractionated in 5 peaks, which accelerated heart rate.
在心电图实验中,大黄蜂(Vespa mandarinia)的粗毒液对大鼠心脏显示出心脏活性作用。腹腔注射毒液后5分钟内心率加快,随后心跳受阻,导致传导延迟。通过凝胶过滤将心脏活性成分分离为两个组分。一种是高分子物质如蛋白质,显示出完全性房室传导阻滞。另一种低分子量组分被分离为5个峰,可加快心率。