Ohmura E, Jansen A, Chernick V, Winter J, Friesen H G, Rivier J, Vale W
Endocrinology. 1984 Jan;114(1):299-301. doi: 10.1210/endo-114-1-299.
The effects of growth hormone-releasing factor, hpGRF (1-40), on plasma GH levels were studied in chronically catheterized ovine fetuses between 71 to 134 days of gestation. The basal ovine (o) GH levels in the fetus ranged between 41 - 144 ng/ml, while values in the ewe were often less than 6 ng/ml. hpGRF (1-40), 5 micrograms/kg infused into a fetal vein, markedly stimulated GH release in all nine fetuses. The maximum increase above pretreatment levels (net increases) ranged from 65 ng/ml to 498 ng/ml, with a mean net increase of 229 ng/ml. The responses of oGH in fetuses at younger gestational age appeared to be greater than in older fetuses. Mean plasma oPRL did not change after hpGRF infusion. These results indicate that somatotrophs in fetal sheep in mid- and late gestation have receptors for GRF, and GH secretion may be modulated by GRF at this stage of gestation.
在妊娠71至134天的慢性插管绵羊胎儿中，研究了生长激素释放因子hpGRF(1 - 40)对血浆生长激素(GH)水平的影响。胎儿中基础绵羊(o)GH水平在41 - 144 ng/ml之间，而母羊中的值通常低于6 ng/ml。将5微克/千克的hpGRF(1 - 40)注入胎儿静脉，显著刺激了所有9只胎儿的GH释放。高于预处理水平的最大增加量(净增加量)在65 ng/ml至498 ng/ml之间，平均净增加量为229 ng/ml。妊娠年龄较小的胎儿中oGH的反应似乎比年龄较大的胎儿更大。注入hpGRF后，平均血浆oPRL没有变化。这些结果表明，妊娠中期和晚期的绵羊胎儿中的生长激素细胞具有GRF受体，并且在妊娠的这个阶段，GH分泌可能受GRF调节。
