Kanba S, Richelson E
Eur J Pharmacol. 1983 Oct 28;94(3-4):313-8. doi: 10.1016/0014-2999(83)90420-x.
Guinea pig hippocampus dissociated by mechanical means into uniform clumps of cells (approximately 100 micron in diameter) contains histamine receptors (H1 and H2) which mediate the formation of cyclic AMP. In this preparation, antidepressants are very potent antagonists of histamine H1 receptors but are weak antagonists of histamine H2 receptors. The latter result is contrary to data derived by others using homogenates of the guinea pig hippocampus and seems to dispel the idea that antidepressants derive their efficacy by blocking histamine H2 receptors in brain.
通过机械方法解离成均匀细胞团块（直径约100微米）的豚鼠海马体含有组胺受体（H1和H2），这些受体介导环磷酸腺苷的形成。在这种制剂中，抗抑郁药是组胺H1受体的强效拮抗剂，但却是组胺H2受体的弱拮抗剂。后一结果与其他人使用豚鼠海马体匀浆得出的数据相反，似乎消除了抗抑郁药通过阻断脑中组胺H2受体发挥疗效的观点。
