Upton G V
Int J Fertil. 1983;28(3):121-40.
The phasic approach to oral contraception is described with a historical review of the evolution of new administration regimens aimed at lowering total steroid content from monophasic to biphasic to the new triphasic approach. The phasic regimen designs which support the intended mechanism of action of each of the phasic approaches are discussed. Emphasis is placed on the discussion of the rationale for the new triphasic oral contraceptive and the clinical demonstration of the triphasic's inhibition of ovulation and maintenance of functional integrity of the pituitary-ovarian axis. A new theoretical formula and practical concept are presented that incorporate a progestogen potency factor, and consequently provide a common denominator enabling a comparison of the magnitude of the effects of various oral contraceptive products on pituitary responsiveness. Widespread clinical studies are described which reinforce the suggestion that the triphasic is the state of the art and represents an important contribution to contraceptive technology.
本文描述了口服避孕药的阶段式给药方法，并对旨在降低总甾体含量的新给药方案的演变进行了历史回顾，这些方案从单相发展到双相，再到新的三相方法。文中讨论了支持每种阶段式方法预期作用机制的阶段式给药方案设计。重点讨论了新型三相口服避孕药的原理以及三相避孕药抑制排卵和维持垂体-卵巢轴功能完整性的临床证据。本文提出了一个新的理论公式和实用概念，其中纳入了孕激素效力因子，从而提供了一个共同标准，以便能够比较各种口服避孕产品对垂体反应性的影响程度。文中还描述了广泛的临床研究，这些研究进一步证实了三相口服避孕药代表了当前的技术水平，是对避孕技术的一项重要贡献。
