Simpson E
Proc R Soc Lond B Biol Sci. 1983 Nov 22;220(1218):31-46. doi: 10.1098/rspb.1983.0087.
H-Y was originally discovered as a transplantation antigen that caused female mice of certain inbred strains to reject skin from otherwise identical males. The ability to make the skin graft rejection response and, in vitro, cytotoxic T cell responses against H-Y is controlled by genes within the major histocompatibility complex, H-2, and by non-H-2 genes. H-Y belongs to a class of weak transplantation antigens characterized by an inability to elicit responses under many conditions. Although genetic factors are very important in determining responsiveness, their action can be modified by immunization procedures. H-Y has been proposed as the differentiation signal that causes the formation of the testes from the undifferentiated gonad in the developing embryo. This hypothesis has been explored by using a series of mice whose karyotype and phenotypic sex are paradoxical.
H-Y最初被发现是一种移植抗原，它能使某些近交系雌性小鼠排斥来自基因相同的雄性小鼠的皮肤。产生皮肤移植排斥反应以及体外针对H-Y的细胞毒性T细胞反应的能力，由主要组织相容性复合体H-2内的基因以及非H-2基因控制。H-Y属于一类弱移植抗原，其特点是在许多情况下无法引发反应。虽然遗传因素在决定反应性方面非常重要，但其作用可通过免疫程序进行调节。有人提出H-Y是导致发育中的胚胎未分化性腺形成睾丸的分化信号。这一假说已通过使用一系列核型和表型性别相互矛盾的小鼠进行了探索。
