Overton D A
Psychopharmacology (Berl). 1983;81(4):340-4. doi: 10.1007/BF00427574.
Five groups of rats were trained to discriminate methysergide, morphine, nicotine, pentobarbital, or scopolamine, respectively, from no injection in a T-maze shock-escape drug discrimination task. After these discriminations were learned, rats received substitution tests, before which they were injected with the training drug and with an additional drug. The additional drugs were mainly transmitter depletors, antagonists, or agonists. The experiment was designed to test whether drug discriminations might be mediated by brain mechanisms operated by one of the manipulated neurotransmitters, and to test whether one discriminable drug could mask or occlude the effects of a second discriminable drug. Neither hypothesis was supported by the results.
在一项T型迷宫电击逃避药物辨别任务中，将五组大鼠分别训练，以辨别甲基麦角新碱、吗啡、尼古丁、戊巴比妥或东莨菪碱与未注射药物的差异。在学会这些辨别后，大鼠接受替代测试，在测试前给它们注射训练药物和另一种药物。另一种药物主要是递质耗竭剂、拮抗剂或激动剂。该实验旨在测试药物辨别是否可能由所操纵的神经递质之一所运作的脑机制介导，以及测试一种可辨别的药物是否能掩盖或遮蔽另一种可辨别的药物的作用。结果均未支持这两种假设。
