Overton D A
Psychopharmacology (Berl). 1977 Jul 18;53(2):195-9. doi: 10.1007/BF00426492.
Rats learned drug vs. drug (D vs. D) or drug vs. no drug (D vs. N) discriminations in a T-maze shock escape task with various doses of pentobarbital, phenobarbital, or ethanol. Dose-effect curves were obtained for each drug using D vs. N training. After D vs. N training with any one of these drugs, rats made D choices during substitution tests with the other two drugs, suggesting drug interchangeability. D vs. D training also showed that pentobarbital and phenobarbital were virtually indistinguishable from one another. However, ethanol was readily discriminated from pentobarbital, showing that the two drugs differed. The results show the utility of D vs. D training as a method for studying drug differences that may be too small to detect with substitution tests.
在T型迷宫电击逃避任务中，大鼠通过不同剂量的戊巴比妥、苯巴比妥或乙醇学习药物对药物（D对D）或药物对无药物（D对N）辨别。使用D对N训练为每种药物获得剂量效应曲线。在用这些药物中的任何一种进行D对N训练后，大鼠在使用其他两种药物的替代试验中做出了D选择，表明药物具有互换性。D对D训练还表明，戊巴比妥和苯巴比妥几乎无法区分。然而，乙醇很容易与戊巴比妥区分开来，表明这两种药物不同。结果表明，D对D训练作为一种研究药物差异的方法是有用的，这些差异可能太小而无法通过替代试验检测到。
