Kelbaek H, Tronier B, Bahnsen M, Munkgaard S, Pedersen H
Scand J Clin Lab Invest. 1983 Nov;43(7):597-601.
Fasting level of somatostatin-like immunoreactivity (SLI) in plasma was measured by a highly sensitive radioimmunoassay in 36 patients with alcoholic liver disease verified by histopathology (10 patients with steatosis and 26 with cirrhosis of the liver). The median value of SLI was markedly elevated in patients with steatosis of the liver as compared to normal subjects, P less than 0.01, while the median value of SLI in the cirrhotic group was even higher, P less than 0.05, as compared to the steatotic group. Correlations of SLI to se-bilirubin and p-coagulation factors 2, 7 and 10 were significant, P less than 0.001 and P less than 0.01, respectively, whereas no correlation to plasma insulin could be elicited. These results suggest that in alcoholic liver disease fasting plasma somatostatin is correlated to the degree of hepatic failure and indicate that the liver is an important site for clearance of portal vein somatostatin.
采用高灵敏度放射免疫分析法，对36例经组织病理学证实的酒精性肝病患者（10例脂肪肝患者和26例肝硬化患者）的血浆空腹生长抑素样免疫活性（SLI）水平进行了测定。与正常受试者相比，脂肪肝患者的SLI中位数显著升高，P<0.01，而肝硬化组的SLI中位数甚至更高，与脂肪肝组相比，P<0.05。SLI与血清胆红素以及凝血因子2、7和10的相关性显著，P分别<0.001和<0.01，而与血浆胰岛素无相关性。这些结果表明，在酒精性肝病中，空腹血浆生长抑素与肝衰竭程度相关，提示肝脏是门静脉生长抑素清除的重要部位。
